Skin Innovation at our Fingertips!

Polynucleotides: What’s so special about these new Biostimulators?

These amazing new Biostimulators contain a highly purified polynucleotide matrix which is able to activate skin bio-regeneration processes both at the level of the dermis (fibroblastic stimulation), and at the deep level (adipose & bone tissue). Polydeoxyribonucleotides (PDRNs) are low molecular weight DNA molecules of natural origin that stimulate cell migration and growth, extracellular matrix (ECM) protein production, and reduce inflammation.

• PDRNs work over time by stimulating the rejuvenation process and toning tissues.
• HA reduces wrinkles and skin depressions.
• Antioxidants, Glutathione defends the skin from free radicals attacks and restores the correct amount of acetylcysteine for proper cellular defence.

The beneficial effects of PDRN at a deep level:

The action of nucleotides in deep tissue is particularly important when analyzing tissue ageing. It activates the right receptors that promote a lipogenic effect. As you can see in the image below, as we age, the deep fat layers are reduced with relative sliding of the superficial tissues that lose the support of an adipose base.

We are focus on the following 3 outstanding products:

1) Nucleoskin

The power of Polynucleotides combined with the efficacy of hyaluronic acid. A Bio-restructuring solution with a slight plumping, lifting and regenerating action.

• High concentration of (PDRNs) – work over time by toning tissues and stimulating the rejuvenation process.
• Slightly cross-linked Hyaluronic Acid in a low concentration – reduces wrinkles and skin depressions
• Glutathione – defends the skin from free radicals and restores the amount of acetyl cystine for proper cellular defence.

This solution is less concentrated with lower density than the classic stand-alone Polynucleotide syringes, and it is injected superficially with a mesotherapy technique.

2) Rich PL

Containing (20mg/ml) in a premixed slightly cross-linked HA. (10mg/ml) – This formulation is able to hydrate, restore volume and stimulate cell production, activating skin fibroblasts and, at the same time, give a strong immediate volumising effect.

• HA content will provide an immediate plumping effect, which after 3-6 months, is substituted by stimulation of long lasting, good, healthy collagen.
• Glutathione, which defends the skin from free radicals and restores the amount of acetyl cystine for proper cellular defence.

This solution has almost as high a concentration of PLLA as the very well-known Sculptra, without the complications associated with Sculptra. Rich PL is already premixed and in stable form, making it safer for practitioners to use and therefore, preventing complications. A full 10 ml vial offers 200mg of PLLA, whilst Sculptra only contains 150mg per vial. This treatment is injected much deeper under the skin or bone using a cannula.

3) NucleoRich PL System

This formulation is unique in that it involves all three components, combining Polynucleotides, HA, PLLA and Glutathione. It has the ability to target at the molecular bio-restructuring level and at the tissue level with a consequent lifting effect.
The components are injected separately over alternating weeks. The outcome provides the benefits of both NucleoSkin and Rich PL in one system.
*Volume and frequency will depend on age and skin quality.